Align is probably one of the best probiotic supplements. The unique patented, strain Bifidobacterium infantis 35624 in Align is not found in any other products. The most notable effect of Align is on Irritable Bowel Syndrome. Many people report miracles after starting on Align. The only concern with Align are the additives, that for some people seem to create problems. I, personally didn't have any problems with the additives, because the doses are so small that they don't have any impact.